Localization of denaturation bubbles in random DNA sequences
نویسندگان
چکیده
منابع مشابه
Localization of denaturation bubbles in random DNA sequences.
We study the thermodynamic and dynamic behaviors of twist-induced denaturation bubbles in a long, stretched random sequence of DNA. The small bubbles associated with weak twist are delocalized. Above a threshold torque, the bubbles of several tens of bases or larger become preferentially localized to AT-rich segments. In the localized regime, the bubbles exhibit "aging" and move around subdiffu...
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The local opening of DNA is an intriguing phenomenon from a statistical-physics point of view, but is also essential for its biological function. For instance, the transcription and replication of our genetic code cannot take place without the unwinding of the DNA double helix. Although these biological processes are driven by proteins, there might well be a relation between these biological op...
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The equilibrium statistical properties of DNA denaturation bubbles are examined in detail within the framework of the Peyrard-Bishop-Dauxois model. Bubble formation in homogeneous DNA is found to depend crucially on the presence of nonlinear base-stacking interactions. Small bubbles extending over fewer than ten base pairs are associated with much larger free energies of formation per site than...
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– A statistical model of DNA, coupling base pair states (unbroken or broken) and thermal chain fluctuations, is formulated and then investigated using an exact solution obtained by transfer kernel techniques. The dependence on temperature and DNA length of the fraction of denaturation bubbles and their correlation length are deduced. Novel results include (i) the melting temperature emerges nat...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0736291100